Tutorial Workshop on Parameter Estimation for Biological Models

NC State University, August 8-11, 2014

Co-organizers: Adam Mahdi, Mette Olufsen and Alun Lloyd.

Confirmed speakers: Joseph DiStefano III (UCLA), Marisa Eisenberg (University of Michigan), Johnny Ottesen (Roskilde University, Denmark), Adam Mahdi (University of Oxford), Andrea Arnold (Case Western/NC State), Tom Banks (NC State), Pierre Gremaud (NC State), Alun Lloyd (NC State), Nikki Meshkat (NC State) and Ralph Smith (NC State).

This workshop is aimed at graduate students (and others) who have an interest in confronting mathematical models with biological data. Tutorials will cover estimation of model parameters and associated uncertainties, parameter identifiability, and uncertainty quantification. Lectures will be accompanied by hands-on computer exercises.

Workshop photo.

Program

All talks and practicals will be in SAS 1102. Click here for abstracts for talks and practicals.

All morning talks and the keynote talk will be available online shortly after their completion. A link to the videos will appear soon.

Keynote talk: J. DiStefano III (5-6pm, Saturday, August 9th)

Friday, August 8th
8:00-9:00 Registration (SAS Hall, rm 4104)
9:00-9:15 Welcome (M.S. Olufsen)
9:15-10:45 Mathematical and Statistical Aspects of Inverse Problems (H.T. Banks) link to talk
10:45-11:15 Coffee break
11:15-12:45 Patient specific modeling of ultradian and circadian oscillations in the endocrine HPA-axis and its relation to depression (J.T. Ottesen) link to talk

12:45-2:30 Lunch break (participants on their own)

2:30-4:30 Hands-on practical: Sensitivity Analysis and Least Squares Parameter Estimation for an Epidemic Model (A.L. Lloyd) CODE

5:00-7:00 Poster session (light refreshments provided)

Saturday, August 9th
9:00-10:30 Introduction to structural and practical identifiability (M. Eisenberg) link to talk
10:30-11:00 Coffee break
11:00-12:30 Identifiability of Linear Compartmental Models (N. Meshkat) slides (apologies, but Nikki’s talk failed to record)

12:30-2:30 Lunch break (participants on their own)

2:30-4:30 Hands-on practical (N. Meshkat, M. Eisenberg and J. DiStefano III) Materials for the practical

4:30-5:00 Coffee break
5:00-6:00 Keynote talk. Alternative Dynamic Systems Biology Models and Their Analyses (J. DiStefano III) link to talk

Sunday, August 10th
9:00-10:30 Introduction to uncertainty quantification (R. Smith) link to talk
10:30-11:00 Coffee break
11:00-12:30 Uncertainties in blood flow calculations and data (P. Gremaud) slides and link to talk

12:30-2:30 Lunch break (participants on their own)

2:30-4:30 Hands on practical: Parameter selection, model calibration, and uncertainty propagation for an HIV Model (R. Smith) Materials for practical and slides from the morning’s presentation.

Monday, August 11th
Note changed start time!
9:30-11:00 Introduction to Kalman filtering in parameter estimation (A. Mahdi) link to talk
11:00-11:30 Coffee break
11:30-12:30 Parameter Estimation in Biochemical Models via ensemble Kalman filtering (A. Arnold) link to talk

Workshop finishes at 12:30pm

Abstracts for talks and practicals.